A Case of Hepatomegaly due to Diabetic Glycogenosis Reversed by Glycemic Control.
- Author:
Jina PARK
1
;
Dae Hoon SONG
;
Jong Suk PARK
;
Joo Young NAM
;
Chul Sik KIM
;
Dol Mi KIM
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Kyung Rae KIM
;
Hyun Chul LEE
;
Hae Ryoung KIM
;
Chan Il PARK
Author Information
1. Department of Internal Medicine, Department of Pathology1, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Diabetic glycogenosis;
Hepatomegaly;
Type 1 diabetes mellitus
- MeSH:
Anorexia;
Biopsy;
Diabetes Mellitus;
Diabetes Mellitus, Type 1;
Diabetes Mellitus, Type 2;
Fatty Liver;
Fibrosis;
Glycogen Storage Disease*;
Hepatitis, Alcoholic;
Hepatocytes;
Hepatomegaly*;
Humans;
Liver;
Liver Function Tests;
Male;
Nausea;
Transaminases;
Young Adult
- From:Journal of Korean Society of Endocrinology
2004;19(2):223-228
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Diabetes mellitus is well known to be associated with various structural and functional liver abnormalities. If diabetic patients are accompanied by hepatomegaly or abnormal findings from a liver function test, the most common pathological findings are steatosis and glycogenosis. The steatosis is characterized by deposition of macrovesicular fat droplets in the hepatocytes, which is common in obese, type 2 diabetes mellitus. If macrovesicular steatosis is combined with mixed inflammatory infiltrate, without evidence of alcoholic hepatitis, the case could be diagnosed as nonalcoholic steatohepatitis (NASH). NASH has the possibility of progressing to cirrhosis. Secondary glycogenosis is common in uncontrolled type 1 diabetes mellitus, and is completely reversible. A 22-year-old male, with uncontrolled type 1 diabetes mellitus, was admitted with anorexia, nausea and right upper quadrant pain. Hepatomegaly and elevated aminotransferases were noted. He was diagnosed as diabetic glycogenosis using computed tomogram and liver biopsy. The hepato megaly and liver function test abnormalities were markedly improved with glycemic control
