The Effects of Dimethly Sulfoxide and Sodium thiosulfate for the Prevention of Tissue Necrosis due to Extravasation of Mitomycin-C.
10.12701/yujm.1996.13.2.243
- Author:
Sang Hyun WOO
;
Byung Cheol CHOI
;
Ki Hyung KIM
;
Jung Hyun SEUL
;
Tae Eun JUNG
- Publication Type:Original Article
- Keywords:
Extravasation injury;
Mitomycn-C;
DMSO;
STS
- MeSH:
Animals;
Dimethyl Sulfoxide;
Injections, Intradermal;
Injections, Subcutaneous;
Mice;
Mitomycin*;
Necrosis*;
Skin Ulcer;
Sodium*;
Ulcer
- From:Yeungnam University Journal of Medicine
1996;13(2):243-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Extravasation of toxic chemotherapeutic 'agents cause severe skin ulceration and necrosis which often need secondary surgical intervention. Still, there were not established antidote agent in case of extravasation with mitomycin-c. Dimethyl sulfoxide is known as an effective chemical scavenger of toxic hydroxyl free radical and sodium thiosulfate also was demonstrated significant protector from mitomycin-c induced ulceration by a few experimental studies. Author investigated necrotic area of mitomycin-c injected site and compare to the effectiveness of topical treatment with dimethyl sulfoxide and intradermal injection of sodium thiosulfate according to starting times, forty five mice were divided into 3 groups. Control group(n=5) had no treatment after subcutaneous injection of mitomycin-c. Experimental group I and 11 were 20 mice treated dimethyl sulfoxide and sodium.
