Prevalence of aspirin sensitivity among asthmatic patients with mild to moderate severity and its clinical characteristics.
- Author:
Jae Young LEE
1
;
Tae Bum KIM
;
Seong Wook SOHN
;
Yoon Suk CHANG
;
Jae Won CHUNG
;
Sang Hoon KIM
;
Yoon Keun KIM
;
Sang Heon CHO
;
Kyung Up MIN
;
You Young KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, drmin@snu.ac.kr
- Publication Type:Original Article
- Keywords:
aspirin-induced asthma;
mild to moderate asthma;
induced sputum;
eosinophil;
airway hyperresponsiveness
- MeSH:
Aspirin*;
Asthma;
Asthma, Aspirin-Induced;
Bronchial Provocation Tests;
Eosinophils;
Humans;
Methacholine Chloride;
Nasal Polyps;
Prevalence*;
Risk Factors;
Sputum
- From:Journal of Asthma, Allergy and Clinical Immunology
2002;22(1):100-108
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: While aspirin sensitivity has been known to be common among patients with severe asthma, its frequency among asthmatics with mild to moderate severity remains to be learned. OBJECTIVES: To elucidate the frequency of aspirin sensitivity and its clinical characteristics among asthma patients with mild to moderate severity. MATERIAL AND METHODS: A total of 96 asthmatics with mild to moderate severity were enrolled. They underwent lysine-aspirin and methacholine bronchial provocation tests, and gave their induced sputum after the lysine-aspirin challenge. RESULTS: FEV1 declined greater than 20% compared with baseline FEV1 in 11 of 96 patients on the lysine-aspirin challenge. The frequency of aspirin sensitivity was higher among patients with enhanced bronchial hyperresponsiveness to methacholine (PC20 < 1 mg/ml) than among those without it (27.3% vs. 6.8%). The frequency was also higher in those with induced sputum eosinophil count higher than 3% than among those without it (38.9% vs. 0%). However, it was not associated with other risk factors such as age, sex, atopy, nasal polyps, and rhinosinusitis. CONCLUSION: More than 10% of mild to moderate asthmatics have aspirin sensitivity even though they have experienced no history of aspirin sensitivity which may be related with bronchial hyperresponsiveness to methacholine and eosinophil activation.
