A case of carbamazepine-induced anticonvulsant hypersensitivity syndrome expressing eosinophilic pneumonia.
- Author:
Pil Ki MIN
1
;
Hye Sun SEO
;
Chang Hun HAN
;
Cheol Woo KIM
;
Jung Won PARK
;
Chein Soo HONG
Author Information
1. Institute of Allergy, Department of Internal Medicine, Yonsei University College of Medicine. pkmin119@yonsei.md
- Publication Type:Case Report
- Keywords:
anticonvulsant hypersensitivity syndrome;
carbamazepine
- MeSH:
Adult;
Anticonvulsants;
Carbamazepine;
Eosinophilia;
Eosinophils*;
Exanthema;
Fever;
Hepatitis;
Humans;
Hypersensitivity*;
Liver;
Lymphatic Diseases;
Phenobarbital;
Phenytoin;
Pulmonary Eosinophilia*
- From:Journal of Asthma, Allergy and Clinical Immunology
2002;22(1):124-128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anticonvulsant hypersensitivity syndrome is a potentially fatal drug reaction with cutaneous and systemic reactions to the arene oxide-producing anticonvulsants: phenytoin, carbamazepine, and phenobarbital. In most cases, the hallmark features of fever, rash, and lymphadenopathy are accompanied by multiorgan-system abnormalities. We experienced a 41-year-old man with a carbamazepine-induced reaction, presenting with fever, rash, eosinophilia, hepatitis, and eosinophilic pneumonia. Because symptoms persisted in spite of discontinuation of carbamazepine, we administered a systemic steroid. After use of the steroid, symptoms were relieved and liver and pulmonary functions improved gradually.
