Progressive Multifocal Leukoencephalopathy in a Patient With Myasthenia Gravis and Thymoma.
- Author:
Hyun Hee KANG
1
;
Jae Hyun PARK
;
Mi Ji LEE
;
Junhun CHO
;
Yeon Lim SUH
;
Su Jin LEE
;
Ju Hong MIN
;
Byoung Joon KIM
;
Seok Geun HAN
Author Information
1. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Myasthenia gravis;
Progressive multifocal leukoencephalopathy;
Thymoma
- MeSH:
Brain;
Consciousness;
DNA;
Female;
Hand;
Humans;
Immunotherapy;
JC Virus;
Leukoencephalopathy, Progressive Multifocal;
Middle Aged;
Myasthenia Gravis;
Thymoma
- From:Journal of the Korean Neurological Association
2012;30(4):312-315
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Progressive multifocal leukoencephalopathy (PML) is a rare and fatal disease caused by JC virus. We report a case of PML which developed in a 61-year-old female patient with myasthenia gravis (MG) and thymoma. After 6 years of immunotherapy and chemotherapy she presented with hand weakness followed by progressive decline of consciousness. Serial brain MRI showed rapidly progressive multifocal white matter changes. The JC virus DNA was detected on cerebrospinal fluid. This is a third report of PML in MG.
