Effects of Eupatilin on the Release of Leukotriene B4 , by Helicobacter pylori - stimulated Neutrophils and Gastric Mucosal Cells.
- Author:
Jung Jin LEE
;
Bok Gee HAN
;
Mal Nam KIM
;
Myung Hee CHUNG
- Publication Type:Original Article
- MeSH:
Helicobacter pylori*;
Helicobacter*;
Inflammation;
Leukotriene B4*;
Leukotrienes;
Neutrophils*
- From:Journal of the Korean Society for Microbiology
1997;32(6):659-666
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Leukotrienes (LTs) are known to act as a mediator provoking tissue response in inflammation. LTs, particularly type B4 (LTB4) as chemotactic factor of neutrophil are released from neutrophils and gastric mucosal cells when these cells are stimulated by Helicobacter pylori. The present study was performed to test a possibility that eupatilin may prevent the H. pylori-induced gastric cell damage by observing whether this chemical inhibit the release of LTB4 from H. pylori-stimulated gastric cells (Kato III) and neutrophils. As observed in the previous study, H. pylori induced the release of LTB4 from these cells and at the same influx of Ca2+ into the cells. In the presence of eupatilin, the release of LTB4 was inhibited whereas Ca2+ influx was not affected. Probably eupatilin may inhibit the release of LTB4 by preventing the synthesis of LTs. These results suggest that eupatilin can has a therapeutic effect on H. pylori-induced gasric cell damage.
