A Case of Acute Kidney Cortex Necrosis Caused by Tranexamic-Acid.
- Author:
Ji Yoon SUNG
1
;
Eul Sik JUNG
;
Shung Han CHOI
;
Dongsu SHIN
;
Hyun Hee LEE
;
Wookyung CHUNG
;
Jae Hyun CHANG
Author Information
1. Department of Internal Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. jhchang@gilhospital.com
- Publication Type:Case Report
- Keywords:
Acute kidney injury;
Kidney cortex necrosis;
Tranexamic acid
- MeSH:
Acute Kidney Injury;
Anuria;
Azotemia;
Bronchiectasis;
Cough;
Female;
Hemorrhage;
Humans;
Kidney;
Kidney Cortex;
Kidney Cortex Necrosis;
Middle Aged;
Renal Dialysis;
Sputum;
Tranexamic Acid
- From:Korean Journal of Medicine
2012;82(4):503-506
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kidney cortex necrosis is a relatively rare cause of acute kidney injury and is characterized by complete or partial destruction of the renal cortex, but sparing of the medulla. Tranexamic acid has antifibrinolytic activity and is used to reduce bleeding. We report a rare case of kidney cortex necrosis caused by tranexamic acid. A 49-year-old woman complained of coughing up blood-tinged sputum. She had a history of bronchiectasis and was treated with tranexamic acid for 3 days. Four days after admission, she developed anuria and azotemia. Computerized tomography showed enhancement of the renal medulla, but not the bilateral renal cortex. The patient was treated with hemodialysis, and has since been maintained on hemodialysis for 6 months. Due to the development of kidney cortex necrosis in patients treated with tranexamic acid, all its potential complications should be considered.
