Effect of remifentanil on QT dispersion.
10.4097/kjae.2009.57.6.737
- Author:
Wonjin LEE
1
;
Young Hwan KIM
;
Kwang Rae CHO
;
Sang Eun LEE
;
Jeong Han LEE
;
Se Hun LIM
;
Kun Moo LEE
;
Soon Ho CHEONG
;
Young Kyun CHOE
;
Young Jae KIM
;
Chee Mahn SHIN
Author Information
1. Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea. anehero@naver.com
- Publication Type:Original Article
- Keywords:
Arrhythmia;
Heart conduction system;
Remifentanil
- MeSH:
Anesthesia, General;
Arrhythmias, Cardiac;
Electrocardiography;
Heart Conduction System;
Humans;
Infusions, Intravenous;
Operating Rooms;
Piperidines;
Population Characteristics;
Risk Factors
- From:Korean Journal of Anesthesiology
2009;57(6):737-741
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: QT dispersion (QT(d)) is an indirect measure of the heterogeneity of ventricular repolarization and can be used as a risk factor for complex ventricular arrhythmias. We measured the effect of remifentanil on QT(d) and heart-rate corrected QT dispersion (QT(cd)). METHODS: Sixty ASA class I and II patients, who were between 20 and 60 years old, and who were scheduled for general anesthesia, were studied. After the patient entered the operating room, a 12 lead EKG recording was taken and intravenous infusion of remifentanil was started. The infusion rate was 0.1 microg/kg/min in group 1 and 0.2 microgram/kg/min in group 2. Another EKG recording was taken 10 minutes after infusion had started. RESULTS: In both groups, QT(d) following remifentanil infusion was not significantly different than control values (76.6 +/- 23.3 ms vs 81.8 +/- 34.9 ms, P = 0.459 in group 1; 70.7 ms +/- 29.7 ms vs 73.7 ms +/- 37.1 ms, P = 0.734 in group 2). Neither was QT(cd): (83.2 ms +/- 25.2 ms vs 89.6 ms +/- 36.2 ms, P = 0.371 in group 1; 81.0 ms +/- 35.2 ms vs 83.4 ms +/- 40.9 ms, P = 0.829 in group 2). CONCLUSIONS: Remifentanil infusion at a rate less than 0.2 microg/kg/min does not change QT(d) or QT(cd).
