Adiponectin Gene Polymorphism and Carotid Artery Intima-Media thickness in Type 2 Diabetes.
10.3803/jkes.2005.20.1.29
- Author:
Eun Seok KANG
1
;
So Young PARK
;
So Hun KIM
;
Hyun Joo LEE
;
Kyu Yeon HUR
;
Seung Jin HAN
;
Se Eun PARK
;
Hyeong Jin KIM
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Kyung Rae KIM
;
Hyun Chul LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Adiponectin;
ACDC;
SNP;
IMT(Intima-Media thickness);
Type 2 diabetes
- MeSH:
Adiponectin*;
Carotid Arteries*;
Carotid Artery, Common;
Genotype;
Humans;
Ultrasonography
- From:Journal of Korean Society of Endocrinology
2005;20(1):29-39
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study was to examine the association between the common polymorphisms of the adiponectin gene(ACDC) and the intima-media thickness(IMT) of the common carotid arteries in type 2 diabetic patients. METHODS: The B mode ultrasound examination of carotid artery was performed on 133 type 2 diabetic patients. The carotid IMT was calculated using the Intimascope computer program. The SNP45 and SNP276 of the ACDC were examined. RESULTS: There was no significant difference in the carotid IMT among the SNP45 genotypes(0.66+/-0.18mm for TT, 0.71+/-0.12mm for TG and 0.64+/-0.15mm for GG, P=NS). Subjects carrying the SNP276 GG genotype had a markedly lower serum adiponectin concentration than those carrying the TT genotype(3.35+/-2.00microgram/mL vs. 4.98+/-2.24microgram/mL, P=0.029) The carotid IMT was significantly higher in patients with the SNP276 GG genotype than those with the TT genotype (0.70+/-0.17mm vs. 0.59+/-0.13mm, P=0.032). Patients with the +45GG/+276GG genotype combination showed significantly higher mean carotid IMT than the other genotype combinations(0.78+/-0.09mm vs. 0.71+/-0.15mm, P=0.013) CONCLUSIONS: These results suggest that the adiponectin gene, SNP276 is associated with the carotid IMT in type 2 diabetic patients. Further studies are will be needed to confirm these genotypephenotype associations.
