Clozapine-induced Agranulocytosis.
- Author:
Hong Shick LEE
1
;
Ji Hyeon KIM
;
Hee Sang LEE
;
Jeong Ho DO
;
Chan Hyung KIM
;
Kae Joon YOO
Author Information
1. Department of Psychiarty, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Schizophrenia;
Clozapine;
Agranulocytosis
- MeSH:
Adult;
Agranulocytosis*;
Anti-Bacterial Agents;
Cefotaxime;
Clozapine;
Humans;
Incidence;
Male;
Natural History;
Neutrophils;
Reference Values;
Schizophrenia
- From:Journal of Korean Neuropsychiatric Association
1997;36(1):204-208
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The authors reported one case of agranulocytosis that occurred in the clozapine treatment in a 34-year-old male patient with chronic schizophrenia. Agranulocytosis, a WBC count of 2700 with 4% neutrophils, developed on Day 25 of clozapine treatment, when clozapine was stopped. On Day 26, he became febrile with temperature of 38 degrees C and he was treated with antibiotics, Claforan for 4 days, and received carefully daily blood monitoring and observation. Six days after stopping the administration of clozapine, his WBC exhibited the normal range with increasing numbers of neutrophils(WBC, 6000/mm3 ; neutrophils, 43%) and he began to improve clinically. Also, we described the recent review of incidence, the natural history and implicated possible mechanisms for clozapine-induced agranulocytosis.
