Angiotensin Converting Enzyme Inhibition Decreases Growth Factor Expression in the Neonatal Rat Kidney.
- Author:
Kee Hwan YOO
;
Haewon CHEON
;
Byung Min CHOI
;
Young Sook HONG
;
Joo Won LEE
;
Soon Kyum KIM
- Publication Type:Original Article
- Keywords:
Angiotensin;
Renin-angiotensin System;
Growth;
TGF-beta1;
EGF
- MeSH:
Angiotensins*;
Animals;
Cell Communication;
Cell Proliferation;
Enalapril;
Epidermal Growth Factor;
Extracellular Matrix;
Fetus;
Growth and Development;
Humans;
Infant, Newborn;
Intercellular Signaling Peptides and Proteins;
Kidney*;
Mortality;
Peptidyl-Dipeptidase A*;
Rats*;
Renin-Angiotensin System;
RNA, Messenger;
Transforming Growth Factor beta1
- From:Korean Journal of Nephrology
1998;17(4):527-533
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The renin-angiotensin system plays an important role in renal growth and development. Exposure of the fetus or neonate to angiotensin converting enzyme (ACE) inhibitors increases mortality, growth retardation, and results in renal anomalies. This study was designed to investigate the effects of ACE inhibition in the neonatal rat on the expression of genes known to modulate renal cellular proliferation, cell interactions, and extracellular matrix. Newborn rat pups were treated with enalapril (30mg/ kg/day) or vehicle for 14 days, and kidneys were removed for determination of mRNA for transforming growth factor-beta 1 (TGF- B1) and prepro epidermal growth factor (EGF). Enalapril treatment resulted in 40Yo mortality by day 14 as well as reduced body and kidney weight (P<0.05 vs vehicle group). Also enalapril decreased renal TGF-Bl and EGF mRNA expression (P<0.05). These results indicate that ACE inhibition in the developing kidney reduces the renal expression of critical growth factors, which may account for renal growth impairment.
