Effect of Hemodialysis on Levels of Malondialdehyde and Antioxidant Enzymes in Erythrocytes from Patients with End Stage Renal Disease.
- Author:
Kyo Cheol MUN
;
Il JOO
;
You Hee KIM
;
Sung Bae PARK
;
Hyun Chul KIM
- Publication Type:Original Article
- Keywords:
Catalase;
Erythrocyte;
Glutathione peroxidase;
Hemodialysis;
Malondialdehyde;
Superoxide dismutase
- MeSH:
Catalase;
Dialysis;
Erythrocytes*;
Glutathione Peroxidase;
Humans;
Kidney Failure, Chronic*;
Lipid Peroxidation;
Malondialdehyde*;
Membranes;
Renal Dialysis*;
Superoxide Dismutase
- From:Korean Journal of Nephrology
1998;17(4):591-596
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To clarify the mechanism of the protective effect of hemodialysis on lipid peroxidation in RBC membrane structures, the level of malondialdehyde (MDA) which is the lipid peroxidation product, and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) were determined before and after hemodialysis in the RBCs from 20 patients with end stage renal disease (ESRD), and from 14 healthy subjects. Before dialysis, MDA levels in the RBCs from the patients with ESRD were higher than those from healthy controls. SOD and catalase activities in the RBCs were lower. After hemodialysis, MDA, SOD, and catalase in the RBCs from the patients with ESRD were normalized. These results indicate that hemodialysis treatment is helpful to protect the peroxidative darnage through normalizing the activities of antioxidant enzymes.
