Minimal Change Disease and Focal Segmental Glomerulosclerosis in Identical Twin Brothers.
- Author:
Hye Young KIM
;
Joong Il PARK
;
Yun Jae CHUNG
;
Yoon Ha LEE
;
Wooseong HUHY
;
Yoon Goo KIM
;
Dae Joong KIM
;
Ha Young OH
;
Young Hyeh KO
- Publication Type:Original Article
- Keywords:
Identical twins;
Focal segmental glomerulosclerosis;
Minimal change disease;
Familial
- MeSH:
Adolescent;
Glomerulonephritis;
Glomerulosclerosis, Focal Segmental*;
Histocompatibility Testing;
Humans;
Korea;
Nephrosis, Lipoid*;
Phenotype;
Proteinuria;
Siblings*;
Twins, Monozygotic*
- From:Korean Journal of Nephrology
1998;17(4):619-623
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The simultaneous occurrence of primary glomerulonephritis in identical twins has been rarely reported previously. It has suggested that genetic factors may play an important role in the pathogenesis of primary glomerulonephritis. We describe a pair of 17-year-old identical twin brothers with asymptomatic proteinuria, one with histologically proven minimal change disease and the other with focal segmental glomerulosclerosis. HLA typing in twin brothers revealed an identical phenotype consisting of A25, A33, B44, B54, Cwl, Cw7, DR7 and DRB1. To our knowledge, this is the first case of glomerulonephritis in identical twins in Korea.
