A Case of Overlapping Syndrome of Primary Membranous Nephropathy and IgA Nephropathy.
- Author:
Tae Seog KIM
;
Mi Kyung CHA
;
Jong Ho LEE
;
Seung Yeon HA
- Publication Type:Case Report
- Keywords:
IgA nephropathy;
Membranous nephropathy;
Overlapping glomerulonephritis
- MeSH:
Adult;
Capillaries;
Female;
Fluorescent Antibody Technique, Direct;
Glomerulonephritis, IGA*;
Glomerulonephritis, Membranous*;
Humans;
Immunoglobulin A*;
Immunoglobulin G;
Mesangial Cells;
Microscopy, Electron;
Nephrotic Syndrome
- From:Korean Journal of Nephrology
1998;17(4):624-628
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a rare case of primary glomerular disease with both features of IgA nephropathy and membranous glomerulonephritis in a 27 year-old woman with nephrotic syndrome. Histologically, glomeruli showed slight mesangial expansion, proliferation of mesangial cells, and short subepithelial spikes on capillary wall. Direct immunofluorescence demonstrated granular IgG and C3 deposits along the capillary walls, and IgA with C3 deposits in mesangium. Granular subepithelial and rnesangial deposits were observed by electron microscopy. The patient showed complete remission after 6 months therapy with steroid and ACE inhibitor.
