A Case of Multiple Endocrine Neoplasia Type 1 with Mutation in MENIN Gene.
10.3803/jkes.2005.20.1.71
- Author:
Se Eun PARK
1
;
Eun Seok KANG
;
Hyun Joo LEE
;
So Hun KIM
;
Mi Young DO
;
Shin Ae KANG
;
Seung Jin HAN
;
Hyeong Jin KIM
;
Chul Woo AHN
;
Bong Soo CHA
;
Sung Kil LIM
;
Kyung Rae KIM
;
Il Jin KIM
;
Hyun Chul LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
Multiple endocrine neoplasia type 1(MEN 1);
Prolactinoma;
Insulinoma;
Hyperparathyroidism;
MENIN gene
- MeSH:
Blood Glucose;
Calcium;
Diagnosis;
Endosonography;
Exons;
Fasting;
Female;
Genes, Tumor Suppressor;
Head;
Humans;
Hyperparathyroidism;
Hypoglycemia;
Insulin;
Insulinoma;
Islets of Langerhans;
Magnetic Resonance Imaging;
Male;
Multiple Endocrine Neoplasia Type 1*;
Multiple Endocrine Neoplasia*;
Pancreas;
Parathyroid Glands;
Pituitary Gland, Anterior;
Prolactin;
Prolactinoma
- From:Journal of Korean Society of Endocrinology
2005;20(1):71-77
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple endocrine neoplasia type 1(MEN 1) is an autosomal dominantly inherited syndrome, characterized by the combined occurrence of tumors of the parathyroid glands, endocrine pancreas, and anterior pituitary gland. The MENIN gene, which is a kind of tumor suppressor gene, is located at the chromosomal locus 11q13. It consists of one untranslated exon and nine exons encoding the menin protein. We report a case of a 22-yearss-old woman with MEN type 1, who was proven to have a mutation in the MENIN gene. The patient was admitted because of repeated hypoglycemia. The fasting plasma glucose level was 32mg/dL. Seventy two hours fasting test showed an the insulin/glucose ratio as 0.33. Endoscopic ultrasonography detected multiple masses on the pancreas. The arterial -stimulated venous sampling(ASVS) with calcium showed sudden step up of insulin at the head and tail portions of the pancreas. The sellar MRI showed a pituitary mass that produced prolactin. Instead of a pathologic diagnosis from operational specimen, the genetic analysis revealed a mutation in the MENIN 1 gene(exon 2, 200~201insAGCCC).
