Rapid Increase in Marrow Fat Content and Decrease in Marrow Perfusion in Lumbar Vertebra Following Bilateral Oophorectomy: An MR Imaging-Based Prospective Longitudinal Study.
10.3348/kjr.2015.16.1.154
- Author:
Yi Xiang J WANG
1
;
James F GRIFFITH
;
Min DENG
;
David KW YEUNG
;
Jing YUAN
Author Information
1. Department of Imaging & Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China. yixiang_wang@cuhk.edu.hk
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Oophorectomy;
Bone mineral density;
Blood perfusion;
Marrow fact content;
Magnetic resonance
- MeSH:
Body Mass Index;
Bone Density;
Bone Marrow/*metabolism;
Contrast Media/diagnostic use;
Female;
Humans;
Hysterectomy;
Lipids/analysis;
Longitudinal Studies;
Lumbar Vertebrae/*radiography;
*Magnetic Resonance Imaging;
Middle Aged;
Ovariectomy;
Prospective Studies
- From:Korean Journal of Radiology
2015;16(1):154-159
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Bilateral oophorectomy leads to reduced bone mineral density (BMD), and reduced BMD is associated with increased marrow fat and reduced marrow perfusion. Purpose of this study was to investigate how soon these changes occur following surgical oophorectomy. MATERIALS AND METHODS: Six patients who underwent hysterectomy and bilateral salpingo-oophorectomy were studied. At baseline, mean patient age was 49.5 years (range: 45-54 years). Third lumbar vertebral body BMD measurement using quantitative CT, marrow fat fraction (FF) using MR spectroscopy and marrow perfusion using dynamic contrast enhanced MRI were conducted immediately prior to surgery and at 3, 9, and 21 months after surgery. RESULTS: Reduced BMD, increased marrow FF, and reduced marrow perfusion occurred synchronously post-oophorectomy. There was a sharp decrease of 12.5 +/- 7.2% in BMD (n = 6), a sharp increase of 92.2 +/- 46.3% (n = 6) in FF, a sharp decrease of 23.6 +/- 3.9% in maximum contrast enhancement (n = 5), and of 45.4 +/- 7.7% for enhancement slope (n = 5) during the initial 3 months post surgery. BMD and marrow perfusion continued to decrease, and marrow FF continued to increase at a slower rate during the following 18 months. Friedman test showed a significant trend for these changes (p < 0.05). CONCLUSION: Bilateral oophorectomy leads to a rapid decrease in lumbar BMD, an increase in marrow fat content, and a decrease in marrow blood perfusion.
