Postnatal weight gain in the first two weeks as a predicting factor of severe retinopathy of prematurity requiring treatment.
- Author:
Jongmoon KIM
1
;
Jang Yong JIN
;
Sung Shin KIM
Author Information
- Publication Type:Original Article
- Keywords: Retinopathy of prematurity; Infant premature; Low birth weight infant; Weight gain; Risk factors
- MeSH: Birth Weight; Body Weight; Gestational Age; Humans; Infant; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Logistic Models; Odds Ratio; Parturition; Retinopathy of Prematurity*; Retrospective Studies; Risk Factors; Weight Gain*
- From:Korean Journal of Pediatrics 2015;58(2):52-59
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: This study aimed to investigate the relative weight gain at 2-week intervals up to 6 weeks after birth to predict retinopathy of prematurity (ROP) requiring treatment among very low birth weight infants. METHODS: A total of 211 preterm infants with birth weights <1,500 g and gestational age <32 weeks were retrospectively reviewed. The main outcome was the development of ROP requiring treatment. Body weight measurements were recorded daily. Relative weight gains (g/kg/day) were calculated at the second, fourth, and sixth week after birth. RESULTS: Of the 211 infants, 89 developed ROP, of which 41 spontaneously regressed and 48 with early treatment of ROP type I required laser treatment. The relative weight gain at 2, 4, and 6 weeks postnatal age was significantly lower in infants with ROP requiring treatment than in infants without ROP or those with spontaneous regression (P<0.001, P=0.005, and P=0.004, respectively). On logistic regression, poor relative weight gain in the first 2 weeks was found to be related to ROP requiring treatment (adjusted odds ratio, 0.809; 95% confidence interval, 0.695-0.941; P=0.006). Relative weight gain at 2 weeks postnatal age was significantly lower in infants with ROP requiring treatment compared to that in ROP requiring no treatment (P=0.012). CONCLUSION: Poor postnatal weight gain in the first 2 weeks of life is an important and independent risk factor for ROP requiring treatment. Postnatal weight gain can predict the development of severe ROP requiring treatment.
