Could Prior Oral-bisphosphonate Administration Reduce the Acute Phase Reaction of Zoledronate?.
- Author:
Sung Hwa SEO
1
;
Hwan Seong CHO
;
Sang Ho CHEON
;
Hye mi JEONG
;
Il Hyung PARK
Author Information
1. Department of Biomedical Sciences, Kyung Pook National University, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Acute phase reaction;
Oral bisphosphonate;
Zoledronic acid
- MeSH:
Acute-Phase Reaction;
Aged, 80 and over;
Arthralgia;
Diphosphonates;
Fever;
Headache;
Humans;
Imidazoles;
Osteoporosis;
Prospective Studies;
Surveys and Questionnaires
- From:Korean Journal of Bone Metabolism
2011;18(1):49-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Bisphosphonates are the most commonly prescribed medications for the treatment of osteoporosis. This study was designed to analyze the rate of acute phase reaction (APR) following Zoledronate 5 mg administration in patients with osteoporosis who were treated with prior oral bisphosphonate for at least 2 weeks and to compare naive IV 5 mg Zoledronate. METHODS: Between July 2009 and October 2010, 27 patients with osteoporosis who were treated with prior oral bisphosphonate for at least 2 weeks, and maximum 52 weeks (average 18.5 weeks) and were between 42-and 85-year-old at the time of study participation. We prospectively evaluated APR, including fever, flu-like symptoms, headache, arthralgia, and myalgia, after 5 mg zoledronate by questionnaire. Additionally we assessed a visual analogue scale (VAS) by 4-point categorical scale. RESULTS: In this study of 27 patients with osteoporosis, the frequency of APR, flu-like symptom and myalgia were 14.8% and 7.4% and fever, arthralgia, and headache were 3.7% respectively. In VAS, all reactions were mild. The rate of APR rate in this study was statistically decreased compared to previous reports with zoledronate 5 mg IV in bisphosphonate-naive patients. CONCLUSION: Prior oral bisphosphonate administration for at least 2 weeks could significantly reduce the APR of IV zoledronate 5 mg.
