The effect of pre-anesthetic administration of dexmedetomidine on the consumption of opioids in postoperative gynecologic patients.
10.17085/apm.2017.12.1.37
- Author:
Kang Yoo LEE
1
;
Woo Yong LEE
;
Kye Min KIM
;
Byung Hoon YOO
;
Sangseok LEE
;
Yun Hee LIM
;
Mun Cheol KIM
;
Jun Heum YON
Author Information
1. Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. sunnyrhee@paik.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Adrenergic alpha-2 receptor agonists;
Dexmedetomidine;
Fentanyl;
Patient-controlled analgesia;
Postoperative pain
- MeSH:
Adrenergic alpha-2 Receptor Agonists;
Analgesia, Patient-Controlled;
Analgesics, Opioid*;
Anesthesia;
Blood Pressure;
Dexmedetomidine*;
Fentanyl;
Heart Rate;
Humans;
Incidence;
Laparotomy;
Pain, Postoperative;
Passive Cutaneous Anaphylaxis;
Prospective Studies
- From:Anesthesia and Pain Medicine
2017;12(1):37-41
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was designed to assess whether pre-anesthetic administration of dexmedetomidine reduces the postoperative consumption of opioids, in patients receiving patient-controlled fentanyl after gynecological laparotomy. METHODS: This was a prospective, randomized, double-blind, controlled study. Ten minutes before induction of anesthesia, 36 patients scheduled for elective gynecological laparotomy were assigned to receive either normal saline (group N) or dexmedetomidine 1 µg/kg (group D). A patient-controlled analgesia (PCA) device was used to administer fentanyl for the postoperative 24 h period. Cumulative fentanyl consumption and pain score were assessed at postoperative 30 min, 6 h and 24 h. Patient's satisfaction for pain control and other side effects (nausea, sedation score) were recorded for all corresponding time points. RESULTS: There was no significant difference between the groups in cumulative fentanyl consumption (Group N: 11.1 ± 3.2 µg/kg, Group D: 10.3 ± 2.9 µg/kg, P value: 0.706). The incidence of side-effects did not differ between the groups. Both groups showed similar blood pressure after anesthesia induction. However, 10 min after anesthesia induction, the heart rates in group D were significantly lower than group N (P = 0.0002). CONCLUSIONS: In patients undergoing gynecological laparotomy, the pre-anesthetic administration of single loading dose dexmedetomidine (1 µg/kg) given 10 min before anesthesia induction did not reduce the PCA consumption of postoperative fentanyl or the pain score.
