Patients with Persistent New-Onset Diabetes after Transplantation Have Greater Weight Gain after Kidney Transplantation.
10.3346/jkms.2013.28.10.1431
- Author:
Yoonjung KIM
1
;
Jung Ryul KIM
;
Heejung CHOI
;
Jung Won HWANG
;
Hye Ryoun JANG
;
Jung Eun LEE
;
Sung Joo KIM
;
Yoon Goo KIM
;
Dae Joong KIM
;
Ha Young OH
;
Wooseong HUH
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wooseong.huh@samsung.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Transplantation;
Diabetes Mellitus;
Obesity
- MeSH:
Adult;
Body Mass Index;
Case-Control Studies;
Diabetes Mellitus, Type 2/*etiology;
Female;
Graft Rejection/prevention & control;
Humans;
Immunosuppressive Agents/therapeutic use;
*Kidney Transplantation;
Male;
Middle Aged;
Retrospective Studies;
Tacrolimus/therapeutic use;
Time Factors;
*Weight Gain
- From:Journal of Korean Medical Science
2013;28(10):1431-1434
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of the present study was to evaluate the difference in BMI pattern between patients with persistent new-onset diabetes after transplantation (P-NODAT) and without new-onset diabetes after transplantation (N-NODAT) in a retrospective matched case-control (1:3) analysis. Thirty-six patients who developed P-NODAT were identified among 186 adult renal transplant recipients with no evidence of pretransplant diabetes mellitus who underwent kidney transplantation from September 1997 to March 2008 and were treated with a triple regimen including tacrolimus. The controls were selected to match the patients for pretransplant BMI, age at transplantation (+/- 5 yr), and date of transplantation (+/- 12 months). Finally, 20 P-NODAT patients and 60 N-NODAT patients were selected. The pre- and posttransplant BMI data were collected every 16 weeks for up to 80 weeks. The clinical characteristics did not differ between the P-NODAT group and N-NODAT group. BMI increased faster in the P-NODAT group than in the N-NODAT group. The mixed-model analysis showed that patients with P-NODAT exhibited a faster increase in BMI. P-NODAT is associated with posttransplant weight gain. The risk of P-NODAT should be considered in patients with rapid weight gain after transplantation.
