Adipokines, insulin-like growth factor binding protein-3 levels, and insulin sensitivity in women with polycystic ovary syndrome.
10.3904/kjim.2013.28.4.456
- Author:
Hyejin LEE
1
;
Jee Young OH
;
Yeon Ah SUNG
Author Information
1. Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. yasung@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Tumor necrosis factor-alpha;
Insulin-like growth factor binding protein 3;
Polycystic ovary syndrome
- MeSH:
Adiponectin/*blood;
Adult;
Biological Markers/blood;
Case-Control Studies;
Female;
Humans;
*Insulin Resistance;
Insulin-Like Growth Factor Binding Protein 3/*blood;
Obesity/blood;
Polycystic Ovary Syndrome/*blood;
Tumor Necrosis Factor-alpha/*blood;
Young Adult
- From:The Korean Journal of Internal Medicine
2013;28(4):456-463
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Many women with polycystic ovary syndrome (PCOS) exhibit insulin resistance. Adipose tissue plays an important role in insulin resistance, and adipokines including tumor necrosis factor (TNF)-alpha and adiponectin are altered in PCOS. Insulin-like growth factor binding protein-3 (IGFBP-3), alone or in conjunction with other adipokines, is also associated with insulin resistance. We evaluated the effects of TNF-alpha, adiponectin, and IGFBP-3 on insulin sensitivity and the relationships among these proteins in women with PCOS. METHODS: We recruited 40 women with PCOS and 40 age- and body mass index (BMI)-matched regular cycling women (controls). The women were divided into obese (BMI > or = 25 kg/m2) and nonobese (BMI < 25 kg/m2) groups. Anthropometric measurements were performed, and serum levels of TNF-alpha, adiponectin, and IGFBP-3 were determined. Insulin sensitivity was estimated using the metabolic clearance rate (MCR) of glucose calculated from the oral glucose tolerance test. RESULTS: Serum levels of TNF-alpha and IGFBP-3 did not differ between the PCOS and control groups, but adiponectin levels in the PCOS group were lower than those in control women in the nonobese group (p < 0.05). TNF-alpha, adiponectin, and IGFBP-3 levels were not correlated with each other in women with PCOS, but a significant positive correlation was observed between adiponectin levels and MCR (p < 0.05). Multiple regression analysis revealed that adiponectin levels were significantly associated with insulin sensitivity (p < 0.05) in women with PCOS. CONCLUSIONS: IGFBP-3 and TNF-alpha levels were not associated with insulin sensitivity, but adiponectin levels were related to insulin sensitivity in women with PCOS.
