Expression of Cyclin D1 Protein in Breast Cancer and Its Correlation with Prognosis.
- Author:
Se Hwan HAN
1
;
Hong Yong KIM
;
Kyeong Mee PARK
;
Myung Soo LEE
;
Hong Joo KIM
;
Young Duck KIM
Author Information
1. Department of Surgery, Inje University Sanggye Paik Hospital.
- Publication Type:Original Article
- Keywords:
Breast cancer;
Cell growth;
Cyclin D1;
Prognosis
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinogenesis;
Cell Cycle;
Cyclin D1*;
Cyclins*;
Flow Cytometry;
Humans;
Incidence;
Prognosis*;
Recurrence;
Sample Size
- From:Journal of the Korean Surgical Society
1999;56(6):771-776
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cyclin D1 is known to be a key regulator in the G1 to S transition of the cell cycle in numerous cases of human neoplasia. We performed immunohistochemical assay (IHC) for cyclin D1 expression in 67 breast cancer tissues to investigate its prognostic implication in breast cancer. METHODS: Protein data for cyclin D1 expression obtained by IHC were merged with the clinical and the biological parameters of the patients, and the recurrence and the survival of the patients were analyzed according to the expression status of cyclin D1. RESULTS: Of 67 breast cancers, 16 cases (23.9%) showed strong expression of cyclin D1 protein. Cyclin D1 expression was significantly increased in larger tumors (p=0.025) but there was no evident correlation between cyclin D1 expression and the clinical and the biological parameters of the studied patients. Although cyclin D1 is a cell cycle regulator essential for the G1 to S transition of the cell cycle, we could not identify any correlation between cyclin D1 expression and the S-phase or the G0/G1 fraction measured by flow cytometry. In the survival analyses, patients with increased expression of cyclin D1 protein had an increased incidence of recurrence and poorer survival than other patients. However, the difference was not statistically significant. CONCLUSIONS: Increased expression of cyclin D1 protein was present in a certain proportion of breast cancer. Overexpression of cyclin D1 seemed to play a role in carcinogenesis and tumor growth. However, the clinical utility of cyclin D1 as a prognostic indicator in breast cancer patients have to be defined further by prospective studies with larger sample sizes.
