Study on Association between Single Nucleotide Polymorphisms of MMP7, MMP8, MMP9 Genes and Development of Gastric Cancer and Lymph Node Metastasis.
10.4166/kjg.2011.58.5.245
- Author:
Ji Hye KIM
1
;
Jung A PYUN
;
Kwang Jae LEE
;
Sung Won CHO
;
Kyu Bum KWACK
Author Information
1. Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Korea. kbkwack@cha.ac.kr
- Publication Type:Original Article ; English Abstract ; Research Support, Non-U.S. Gov't
- Keywords:
Stomach neoplasms;
Lymph node metastasis;
Metalloproteinase 7;
Metalloproteinase 8;
Metalloproteinase 9
- MeSH:
Adult;
Age Factors;
Aged;
Alleles;
Chronic Disease;
Female;
Genotype;
Humans;
Logistic Models;
Lymphatic Metastasis;
Male;
Matrix Metalloproteinase 7/*genetics;
Matrix Metalloproteinase 8/*genetics;
Matrix Metalloproteinase 9/*genetics;
Middle Aged;
Neoplasm Staging;
Odds Ratio;
Polymorphism, Single Nucleotide;
Risk Factors;
Sex Factors;
Stomach Neoplasms/*genetics
- From:The Korean Journal of Gastroenterology
2011;58(5):245-251
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Matrix metallopeptidase (MMP) is known to be involved in tumor invasion and metastasis of cancer. This study investigated the association of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 with gastric cancer (GC) development and lymph node metastasis (LNM). METHODS: Samples were obtained from 326 chronic gastritis (CG) and 153 GC patients and genotyped by using the GoldenGate(R) method. Chi-square test was performed to identify the difference of allele distribution between each group (CG vs. GC; CG vs. with LNM GC). The associations of genotype with risk of GC and LNM were estimated by odds ratio and the 95% confidence interval was calculated by logistic regression adjusting for age and sex. RESULTS: The allele and genotype frequencies of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 were not associated with the development of GC and LNM. CONCLUSIONS: In summary, MMP7 rs11568818, MMP8 rs11225395 MMP9 rs17576 and rs2250889 were not associated with the GC development and LNM in Korean population.
