A Clinical Observation on Lupus Nephritis in Children.
- Author:
Kang Mo AHN
;
Jae Sung KO
;
Hye Won PARK
;
Il Soo HA
;
Hae Il CHEONG
;
Yong CHOI
;
Hee Joo KIM
- Publication Type:Original Article
- MeSH:
Anorexia;
Child*;
Cytotoxins;
Early Diagnosis;
Exanthema;
Female;
Fever;
Follow-Up Studies;
Humans;
Immunologic Tests;
Lupus Nephritis*;
Male;
Nephrotic Syndrome;
Renal Insufficiency;
Retrospective Studies;
Survival Rate;
Weight Loss
- From:Journal of the Korean Pediatric Society
1994;37(6):842-849
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We reviewed the clinical features, histrologic patterns and clinical courses of 30 children with lupus nephritis retrospectively, and the results were summerized as follows; 1) The male to female ratio was 1:2.8, and the mean age at the onset was 10 8/12 years. 2) The clinical symptoms were diverse, and malaise, weight loss, anorexia, fever and malar rash were the most frequent findings. 3) Among the immunologic tests, FANA and anti-ds-DNA test revealed the highest sensitivity with positive rates of 97% and 87%, respectively. 4) Clinically, 57% of patients had active nephrotic syndrome at the onset, and 33% showed (?) was the most common findings (70%). 5) During the follow-up period, one children with Class IV lupus nephritis expired. And 8 out of 9 cases with renal insufficiency at the onset showed improvement of renal function after treatment with corticosteroid and cytotoxic agents. In conclusion, the clinical features and histologic findings of lupus nephritis in children were diverse. Early diagnosis and proper treatment can prevent rapid deterioration of renal function and improve long-term survival rate.
