Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1.
10.4093/dmj.2012.36.4.275
- Author:
Hannah SEOK
1
;
Ji Young LEE
;
Eun Mi PARK
;
Se Eun PARK
;
Jae Hyuk LEE
;
Seungtaek LIM
;
Byung Wan LEE
;
Eun Seok KANG
;
Hyun Chul LEE
;
Bong Soo CHA
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. bscha@yuhs.ac
- Publication Type:Original Article
- Keywords:
Balsamic vinegar;
Islets;
Insulin;
ABCA1;
Diet, high-fat
- MeSH:
Acetic Acid;
Animals;
Cholesterol;
Diet;
Diet, High-Fat;
Glucose Tolerance Test;
Insulin;
Rats;
Water
- From:Diabetes & Metabolism Journal
2012;36(4):275-279
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study was to investigate the effects of balsamic vinegar on beta-cell dysfunction. METHODS: In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter. RESULTS: In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased beta-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels. CONCLUSION: These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of beta-cell function via increasing beta-cell ABCA1 expression.
