A Case of Epidermolysis Bullosa Acquisita Associated with Psoriasis.
- Author:
Ki Rang MOON
1
;
Sook Jung YUN
;
Seong Jin KIM
;
Seung Chul LEE
;
Young Ho WON
;
Jee Bum LEE
Author Information
1. Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. jbmlee@jnu.ac.kr
- Publication Type:Case Report
- Keywords:
Epidermolysis bullosa acquisita;
Psoriasis vulgaris
- MeSH:
Antibodies;
Autoantibodies;
Blister;
Collagen Type VII;
Eosinophils;
Epidermolysis Bullosa Acquisita*;
Epidermolysis Bullosa*;
Fluorescent Antibody Technique, Indirect;
Humans;
Immunoblotting;
Immunoglobulin G;
Middle Aged;
Neutrophils;
Pemphigoid, Bullous;
Prednisolone;
Psoriasis*;
Skin
- From:Korean Journal of Dermatology
2016;54(6):464-467
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Epidermolysis bullosa acquisita (EBA) is an autoimmune subepidermal blistering disease characterized by the presence of circulating IgG autoantibodies to type VII collagen. Various types of autoimmune blistering disease have been reported in association with psoriasis. A 58-year-old man with a 5-year history of psoriasis vulgaris presented with painful and mildly pruritic erythematous multiple bullae and vesicles. Histopathologically, there was a subepidermal bulla with infiltration of inflammatory cells composed of neutrophils and eosinophils. The salt-split skin indirect immunofluorescence test showed IgG binding to the dermal side of the separation, and immunoblotting using normal human dermal extract revealed antibodies directed against a 290-kDa polypeptide. He was diagnosed with EBA and started medication of oral prednisolone and mycophenolate mofetil. Skin lesions were continuously regressed. Of all the autoimmune blistering diseases coexisting with psoriasis, bullous pemphigoid is the most frequent. However, a few cases of EBA associated with psoriasis have been reported in the literature. We report a rare case of EBA coexisting with psoriasis vulgaris.
