Two Cases of Acute Retinal Necrosis Treated With Systemic Antiviral Drugs and Intravitreal Antiviral Injections.
10.3341/jkos.2009.50.5.794
- Author:
Ji Wook YANG
1
;
Wung Jae KIM
;
Young Hoon PARK
Author Information
1. Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea. parkyh@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Acute retinal necrosis;
Gancyclovir;
Intravitreal injection
- MeSH:
Acyclovir;
Antiviral Agents;
Follow-Up Studies;
Ganciclovir;
Humans;
Intravitreal Injections;
Retinal Necrosis Syndrome, Acute;
Retinitis;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2009;50(5):794-799
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:To report the use of intravitreal antiviral injections as adjunctive therapy in the managementof two immunocompetent patients with acute retinal necrosis. CASE SUMMARY: We performed two or three intravitreal injections of gancyclovir (2,000 microg/0.05 ml) on two patients (two eyes) with acute retinal necrosis resistant to intravenous acyclovir therapy (1,500 mg/m2/day). Both patients received intravitreal antiviral injections for the treatment of retinitis that progressed despite standard intravenous acyclovir therapy. The retinitis resolved, and visual acuity improved after 18 months of follow-up in both cases. CONCLUSIONS: Intravitreal antiviral injections may be a safe and efficacious adjunctive therapy in the management of patients with acute retinal necrosis resistant to intravenous acyclovir therapy.
