Diagnostic Value of Systematic Sextant and Lesion Directed Biopsy Regimen in Patients with Suspicious Lesions on Transrectal Ultrasonography.
10.4111/kju.2006.47.7.747
- Author:
Sang Wook LEE
1
;
Sung Kyu HONG
;
Seok Soo BYUN
;
Sang Eun LEE
;
Kwan Joong JOO
Author Information
1. Department of Urology, Seoul National University College of Medicine, Seoul, Korea. ssbyun@snubh.org
- Publication Type:Original Article
- Keywords:
Biopsy;
Diagnosis;
Prostatic neoplasm;
Ultrasonography
- MeSH:
Biopsy*;
Diagnosis;
Digital Rectal Examination;
Humans;
Male;
Prostate;
Prostate-Specific Antigen;
Prostatic Neoplasms;
Ultrasonography*
- From:Korean Journal of Urology
2006;47(7):747-751
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the diagnostic value of systematic sextant and lesion directed biopsy regimen in patients with hypoechoic lesions on transrectal ultrasonography (TRUS) for the detection of prostate cancer. MATERIALS AND METHODS: Between September 2003 and November 2005, a total of 142 men with sonomorphologic lesions suggestive of prostate cancer on TRUS underwent prostate biopsy. In all the subjects, lesion directed biopsies were taken in addition to the systematic 12 core biopsies. We examined the cancers detected in only the lateral region of 12 cores and the cancers detected in only the lesion directed biopsy, as well as the overall cancer detection rate. And, we compared the cancer detection rates of sextant and lesion directed biopsy, 12 core biopsy, and 12 core and lesion directed biopsy strategy. RESULTS: Of the 142 patients who underwent 12 core and lesion directed biopsy, 48 patients (33.8%) were diagnosed as having prostate cancer. The prostate cancer detection rate for systematic sextant and lesion directed biopsy and for 12 core biopsy was 28.9% (41/142) and 31.0% (44/142), respectively. There was no significant difference in the overall cancer detection rate between the three biopsy strategies (p=0.667). Also, when stratified by prostate-specific antigen (PSA) level, prostate volume, and digital rectal examination (DRE) findings, there was no significant difference in cancer detection rate between the three regimens. CONCLUSIONS: The systematic sextant and lesion directed biopsy strategy for patients with focal hypoechoic lesions on TRUS is an adequate and reasonable approach for the detection of prostate cancer with a relatively small number of biopsy cores.
