An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation.
- Author:
Ying Jie MA
1
;
Bok Luel LEE
;
Peter GARRED
Author Information
- Publication Type:Review
- MeSH: Collectins; Complement Activation*; Complement System Proteins*; Inflammation
- From:Experimental & Molecular Medicine 2017;49(4):e320-
- CountryRepublic of Korea
- Language:English
- Abstract: The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation.
