Phenotype Difference between Familial and Sporadic Ankylosing Spondylitis in Korean Patients.
10.3346/jkms.2014.29.6.782
- Author:
Hye Won KIM
1
;
Hye Rim CHOE
;
Su Bin LEE
;
Won Ik CHANG
;
Hyun Jun CHAE
;
Jin Young MOON
;
Jisue KANG
;
Sungim LEE
;
Yeong Wook SONG
;
Eun Young LEE
Author Information
1. Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Spondylitis, Ankylosing;
Familial;
Sporadic;
Phenotype;
Recurrence Risk
- MeSH:
Adult;
Age Factors;
Arthritis, Juvenile/diagnosis/epidemiology;
Blood Sedimentation;
Body Mass Index;
C-Reactive Protein/analysis;
Demography;
Family;
Female;
HLA-B27 Antigen/metabolism;
Humans;
Interviews as Topic;
Male;
Middle Aged;
Phenotype;
Recurrence;
Republic of Korea;
Risk Factors;
Severity of Illness Index;
Sex Factors;
Spondylitis, Ankylosing/*diagnosis
- From:Journal of Korean Medical Science
2014;29(6):782-787
- CountryRepublic of Korea
- Language:English
-
Abstract:
Clustered occurrences of ankylosing spondylitis (AS) in family have been noticed. We evaluated patients with AS confirmed by the modified New York criteria for familial history of AS (one or more first to third degree relatives). The clinical characteristics and the recurrence risks (number of AS patients/number of familial members) of the familial AS compared to sporadic AS were investigated. Out of a total of 204 AS patients, 38 patients (18.6%) reported that they had a familial history of AS. The recurrence risks in the familial AS patients for first, second and third degree family members were 14.5%, 5.2%, and 4.4% respectively. Erythrocyte sedimentation rate (ESR) (22.6+/-22.2 vs 35.4+/-34.4, P=0.029) and C-reactive protein (CRP) (1.24+/-1.7 vs 2.43+/-3.3, P=0.003) at diagnosis, body mass index (21.9+/-2.7 vs 23.7+/-3.3, P=0.002) and frequency of oligoarthritis (13.2% vs 33.7%, P=0.021) were significantly lower in the familial form. The presence of HLA-B27 (97.4% vs 83.1%, P=0.044) was significantly higher in familial AS. In conclusion, Korean familial AS patients show a lower frequency of oligoarthritis, lower BMI, lower ESR and CRP at diagnosis and higher presence of HLA-B27.
