The Effect of Body Mass Index on Survival in Advanced Epithelial Ovarian Cancer.
10.3346/jkms.2014.29.6.793
- Author:
Hyo Sook BAE
1
;
Jin Hwa HONG
;
Kyoung Do KI
;
Jae Yun SONG
;
Jin Woo SHIN
;
Jong Min LEE
;
Jae Kwan LEE
;
Nak Woo LEE
;
Chan LEE
;
Kyu Wan LEE
;
Yong Min KIM
Author Information
1. Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Ovarian Neoplasms;
Survival;
Body Mass Index;
Obesity
- MeSH:
Adolescent;
Adult;
Aged;
*Body Mass Index;
Female;
Humans;
Kaplan-Meier Estimate;
Middle Aged;
Neoplasm Staging;
Neoplasms, Glandular and Epithelial/*diagnosis/mortality/pathology;
Ovarian Neoplasms/*diagnosis/mortality/pathology;
Proportional Hazards Models;
Retrospective Studies;
Risk Factors;
Young Adult
- From:Journal of Korean Medical Science
2014;29(6):793-797
- CountryRepublic of Korea
- Language:English
-
Abstract:
Controversy remains regarding the effect of obesity on the survival of patients with ovarian cancer in Asia. This study examined the impact of obesity on the survival outcomes in advanced epithelial ovarian cancer (EOC) using Asian body mass index (BMI) criteria. The medical records of patients undergoing surgery for advanced (stage III and IV) EOC were reviewed. Statistical analyses included ANOVA, chi-square test, Kaplan-Meier survival and Cox regression analysis. Among all 236 patients, there were no differences in overall survival according to BMI except in underweight patients. In a multivariate Cox analysis, surgical optimality and underweight status were independent and significant prognostic factors for survival (HR, 2.302; 95% CI, 1.326-3.995; P=0.003 and HR, 8.622; 95% CI, 1.871-39.737; P = 0.006, respectively). In the subgroup of serous histology and optimal surgery, overweight and obese I patients showed better survival than normal weight patients (P = 0.012). We found that underweight BMI and surgical optimality are independent risk factors for the survival of patients with advanced ovarian cancer. High BMI groups (overweight, obese I and II) are not associated with the survival of advanced EOC patient. However, in the subgroup of EOC patients with serous histology and after optimal operation, overweight and obese I group patients show better survival than the normal weight group patients.
