Nonleukemic Granulocytic Sarcoma in the Bile Duct: A Case Report.
10.3346/jkms.2006.21.4.745
- Author:
Hyun Woo KIM
1
;
Seong Jun CHOI
;
Je Hwan LEE
;
Jung Hee LEE
;
Taeg Soo KIM
;
Yong Gil KIM
;
Jeong Min KANG
;
Jooryng HUH
;
Kwang Min PARK
;
Kyoo Hyung LEE
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea. sjchoi3@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Sarcoma, Granulocytic;
Bile Ducts;
Leukemia, Myelocytic, Acute
- MeSH:
Tomography, X-Ray Computed/methods;
Sarcoma, Granulocytic/*diagnosis/metabolism/radiography;
Radiography, Abdominal;
Peroxidase/analysis;
Male;
Immunohistochemistry;
Humans;
Diagnosis, Differential;
Bile Ducts/chemistry/pathology;
Bile Duct Neoplasms/*chemically induced/metabolism/radiography;
Antigens, CD45/analysis;
Adult
- From:Journal of Korean Medical Science
2006;21(4):745-748
- CountryRepublic of Korea
- Language:English
-
Abstract:
Granulocytic sarcoma (GS) is an extramedullary tumor composed of immature myeloid cells, typically occurring during the course of acute myelogenous leukemia. Non-leukemic GS, that is, GS with no evidence of overt leukemia and no previous history of leukemia, is very rare, and even more unusual is nonleukemic GS of the bile duct. We report a case of nonleukemic GS of the bile duct. The patient was initially misdiagnosed as a bile duct carcinoma arising in the hilum of the liver (so-called Klatskin tumor), and received a right lobectomy of the liver. Histological examination of the tumor yielded the diagnosis of GS, and the bone marrow biopsy did not show any evidence of leukemia. Considering the risk of subsequent development of overt leukemia, the patient was treated with two cycles of combination chemotherapy as used in the cases of acute myelogenous leukemia. To date, he has remained free of disease 15 months after treatment.
