Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner.
- Author:
Mi Eun LEE
1
;
So Ra KIM
;
Seungkoo LEE
;
Yu Jin JUNG
;
Sun Shim CHOI
;
Woo Jin KIM
;
Jeong A HAN
Author Information
1. Department of Biochemistry and Molecular Biology, Institute of Medical Sciences, Kangwon National University School of Medicine, Chuncheon 200-701, Korea. gshja@kangwon.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
caveolin-1;
cyclooxygenase inhibitors;
procollagen;
skin aging
- MeSH:
Animals;
Aspirin/administration & dosage;
Catalysis;
Caveolin 1/genetics/metabolism;
Collagen Type I/genetics/metabolism;
*Cyclooxygenase 2/metabolism/physiology;
Cyclooxygenase 2 Inhibitors/*administration & dosage;
Gene Expression Regulation;
Mice;
Nitrobenzenes/*administration & dosage;
Pyrazoles/administration & dosage;
Skin Aging/*drug effects/physiology;
Sulfonamides/*administration & dosage;
Tumor Suppressor Protein p53/genetics/metabolism
- From:Experimental & Molecular Medicine
2012;44(9):536-544
- CountryRepublic of Korea
- Language:English
-
Abstract:
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a causal factor for aging and whether COX-2 inhibitors could prevent aging. We here examined the effect of COX-2 inhibitors on aging in the intrinsic skin aging model of hairless mice. We observed that among two selective COX-2 inhibitors and one non-selective COX inhibitor studied, only NS-398 inhibited skin aging, while celecoxib and aspirin accelerated skin aging. In addition, NS-398 reduced the expression of p53 and p16, whereas celecoxib and aspirin enhanced their expression. We also found that the aging-modulating effect of the inhibitors is closely associated with the expression of type I procollagen and caveolin-1. These results suggest that pro-inflammatory catalytic activity of COX-2 is not a causal factor for aging at least in skin and that COX-2 inhibitors might modulate skin aging by regulating the expression of type I procollagen and caveolin-1.
