Four Cases of Atopic Dermatitis with Topical Tacrolimus Therapy.
- Author:
Kyung Ok CHAE
1
;
Hyung Ok KIM
;
Chung Won KIM
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Atopic dermatitis;
Tacrolimus
- MeSH:
Calcineurin;
Dermatitis, Atopic*;
Humans;
Soil;
T-Lymphocytes;
Tacrolimus*
- From:Korean Journal of Dermatology
2002;40(1):112-114
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tacrolimus is a macrolide antibiotic that was isolated from soil microorganism. Its mechanism of action is based on calcineurin inhibition, which results in suppression of antigen-specific T-cell activation and inhibition of inflammatory cytokine release. Four patients with atopic dermatitis participated in this study of the efficacy of topical tacrolimus. Our cases showed significant improvement in the signs and symptoms of atopic dermatitis within a week of starting topical tacrolimus. We report 4 cases of atopic dermatitis treated with 0. 1% tacrolimus ointment.
