Fresh Frozen Plasma in Pump Priming for Congenital Heart Surgery: Evaluation of Effects on Postoperative Coagulation Profiles Using a Fibrinogen Assay and Rotational Thromboelastometry.
10.3349/ymj.2013.54.3.752
- Author:
Jong Wha LEE
1
;
Young Chul YOO
;
Han Ki PARK
;
Sou Ouk BANG
;
Ki Young LEE
;
Sun Joon BAI
Author Information
1. Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. bsj8728@gmail.com
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Congenital heart disease;
cardiopulmonary bypass;
blood coagulation disorder;
fresh frozen plasma
- MeSH:
Adolescent;
*Blood Coagulation;
Cardiac Surgical Procedures;
Cardiopulmonary Bypass/methods;
Child;
Child, Preschool;
Female;
Fibrinogen/*metabolism;
Heart Defects, Congenital/*surgery;
Humans;
Infant;
Male;
*Plasma;
Postoperative Period;
Thrombelastography/methods
- From:Yonsei Medical Journal
2013;54(3):752-762
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: In this prospective study, the effects of fresh frozen plasma (FFP) included in pump priming for congenital heart surgery in infants and children on post-bypass coagulation profiles were evaluated. MATERIALS AND METHODS: Either 20% albumin (50-100 mL) or FFP (1-2 units) was added to pump priming for patients randomly allocated into control or treatment groups, respectively. Hematologic assays, including functional fibrinogen level, and rotational thromboelastometry (ROTEM(R)) were measured before skin incision (baseline), after weaning from cardiopulmonary bypass (CPB) and heparin reversal, and at 24 hours (h) in the intensive care unit (ICU). RESULTS: All the baseline measurements were comparable between the control and treatment groups of infants and children. After heparin reversal, however, significantly higher fibrinogen levels and less reduced ROTEM parameters, which reflect clot formation and firmness, were demonstrated in the treatment groups of infants and children. At 24 h in the ICU, hematologic assays and ROTEM measurements were comparable between the control and treatment groups of infants and children. Transfusion requirements, excluding FFP in pump prime, and postoperative bleeding were comparable between the control and treatment groups of infants and children. CONCLUSION: Although clinical benefits were not clearly found, the inclusion of FFP in pump priming for congenital heart surgery in infants and children was shown to improve the hemodilution-related hemostatic dysfunction immediately after weaning from CPB and heparin reversal.
