The effects of polylactic/polyglycolic copolymer (PLA/PGA) membrane on the healing of 1-wall intrabony defects in beagle dogs.
10.5051/jkape.2003.33.4.599
- Author:
Sung Koo KIM
1
;
Sung Joon HWANG
;
Min Kyoung KIM
;
Chang Sung KIM
;
Doug Youn LEE
;
Yong Keun LEE
;
Kyoo Sung CHO
;
Jung Kiu CHAI
;
Chong Kwan KIM
;
Seong Ho CHOI
Author Information
1. Department of Periodontology, College of Dentistry, Yonsei University, Oral Science Research Institute, College of Dentistry, Yonsei University, Korea.
- Publication Type:Original Article
- Keywords:
PLA/PGA membrane;
calcium phosphate;
1-wall defects;
periodontal regeneration
- MeSH:
Animals;
Bone Regeneration;
Calcium;
Connective Tissue;
Dental Cementum;
Dogs*;
Epithelial Attachment;
Humans;
Male;
Mandible;
Membranes*;
Periodontium;
Regeneration;
Transplants
- From:The Journal of the Korean Academy of Periodontology
2003;33(4):599-613
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The goal of periodontal treatment is regeneration of the periodontium. Bone graft and absorbable PLA/PGA membrane have been used for this purpose. In this study, 4x4mm 1-wall intrabony defects were surgically created bilaterally in the mandible of five male beagles. The control group went through a conventional flap operation, while the experimental group I was treated with absorbable PLA/PGA membranes only, group II was treated with absorbable membrane and calcium phosphate. The results are the following : 1. The defect height was 4.82+/-0.45mm in the control group, 4.93+/-0.79mm in the experimental I group, and 4.92+/-0.62mm in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05). 2. The amount of junctional epithelium migration was 30.90+/-9.92% of the defect height in the control group, 39.16+/-7.51% in the experimental I group, and 38.68+/-12.22% in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05). 3. The amount of connective tissue adhesion was 36.38+/-9.03% in the control group, 14.73+/-3.93% in experimental I group, and 27.87+/-9.70% experimental II group. Experimental group I was a statistically significantly different from control group(P<0.05). 4. The amount of new cementum regeneration was 32.92+/-10.51%, 50.04+/-7.61%, and 39.62+/-12.14% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05). 5. The amount of new alveolar bone regeneration was 27.24+/-7.49%, 40.75+/-8.03%, and 36.47+/-15.11% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05). The results suggest that the use of PLA/PGA membrane in 1-wall intrabony defect of beagle dogs may promote periodontal regeneration. Further studies are required to determine their regeneration effects.
