Late-Onset Narcolepsy with Cataplexy Unresponsive to Intravenous High-Dose Immunoglobulin Treatment.
- Author:
Jae Wook CHO
1
;
Na Yeon JUNG
;
Jin Won BAE
;
Dae Jin KIM
;
Jae Hyeok LEE
;
Takashi KANBAYASHI
Author Information
1. Department of Neurology, Pusan National University Yangsan Hospital, Medical Research Institute of Pusan National University, Yangsan, Korea. sleep.cho@gmail.com
- Publication Type:Case Report
- Keywords:
Narcolepsy with cataplexy;
Intravenous immunoglobulins
- MeSH:
Autoimmunity;
Cataplexy;
Humans;
Immunoglobulins;
Immunoglobulins, Intravenous;
Immunotherapy;
Intracellular Signaling Peptides and Proteins;
Korea;
Narcolepsy;
Neuropeptides;
Orexins
- From:Journal of the Korean Neurological Association
2012;30(1):57-59
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Narcolepsy with cataplexy (NC) is associated with hypocretin deficiency, and is thought to be an autoimmunity condition. The mean age at onset is estimated to be in the early 20s. Recent papers have addressed the response to immunotherapies in NC, with challenging results. We report a case of late-onset NC in a patient who did not benefit from early intravenous high-dose immunoglobulin (IVIg) therapy. This is the first reported attempt at using IVIg to treat an NC patient in Korea.
