Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats.
10.14405/kjvr.2017.57.3.181
- Author:
Ju Youn JIN
1
;
Eun Hye PARK
;
Yoon A JEON
;
Young Jae LEE
Author Information
1. College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. yjlee3@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Aralia elata;
hypertension;
lipid peroxidation;
nitic oxide
- MeSH:
Acetylcholine;
Administration, Oral;
Amlodipine;
Animals;
Aorta;
Aralia*;
Blood Pressure;
Ethanol*;
Hypertension;
Lipid Peroxidation;
Malondialdehyde;
Nitroprusside;
Norepinephrine;
Organ Size;
Plasma;
Rats;
Rats, Inbred SHR*
- From:Korean Journal of Veterinary Research
2017;57(3):181-187
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine (10⁻¹⁰–10⁻³ M) in norepinephrine (NE)-precontracted aorta were increased in AE- and Am-treated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside (10⁻¹⁰–10⁻³ M) in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.
