Light Microscopic Study of the Ovary in Patients Receiving Chemotherapy.
- Author:
Eun Joo CHOI
;
Soon Do CHA
;
Yoon Jung PARK
;
Dong Ho NAM
;
Eun Woo LEE
;
Tae Sung LEE
;
Tak LEE
;
Kwan Kyu PARK
- Publication Type:Original Article
- MeSH:
Cervix Uteri;
Cisplatin;
Corpus Luteum;
Drug Therapy*;
Drug Therapy, Combination;
Estrogens, Conjugated (USP);
Female;
Fluorouracil;
Hemorrhage;
Humans;
Induction Chemotherapy;
Microscopy;
Oocytes;
Ovariectomy;
Ovary*;
Ovum
- From:Korean Journal of Gynecologic Oncology and Colposcopy
1993;4(4):81-89
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To examine the cytotoxic effect of chemotherapy on the ovary, 23 cases undergoing oophorectomy with radical hysterect,orny in premenopausal wemen receiving induction chemotherapy with cisplatin and 5-fluomouracil for carcinoma of the cervix between March, 1989 and December, 1992 were studied by light microscopy. Out of 23 cases, 19 (82.6%) showed vascular congestion and 12(52.1%) revealed hemorrhage around folliele and within corpus luteum. The follicular structure was desLroyed in 16 cnses (69.5%) and oocytes of ovums were lost in 17 cases. The mechanism of injury of the ovarian structures after combination chemotherapy with cisplatin and 5-fluorouracil is considered to be caused by secondary cell damage following circulatory disturbance of direct toxicity on fallicular cells of oocytes.
