DNA Analysis of Hydatidiform Mole by Flow Cytometry and Its Relation to the Prognosis.
- Author:
Sook CHO
;
Seung Jo KIM
- Publication Type:Original Article
- MeSH:
Aneuploidy;
Cell Cycle;
Diploidy;
DNA*;
Female;
Flow Cytometry*;
Hydatidiform Mole*;
Ploidies;
Pregnancy;
Prognosis*;
Remission, Spontaneous;
Trophoblasts
- From:Korean Journal of Gynecologic Oncology and Colposcopy
1993;4(4):110-117
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Flow cytometric analyms was performed to investigate any relationship between DNA content and clinical outcome in 32 complete hydatidiform moles (CHMs) and 12 partial hydatidiform moles (PHMs). Twenty three and nine of the 32 CHMs were diploid and aneuploid moles, respectively. Of these 23 diploid CHMs, eight (34.8%) regressed spontaneausly and 15 (65.2%) progressed to persiatent gestatiaoal trophoblastic disease (PGTD). Among nine aneuploid CHMs studied, six (66.7%) underwent spontaneous regremion and three (33.3%) required treatment for peraistent GTI). The twelve PHMs consiated of 9 diploid and 3 aneuploid moles, Three of the rune diploid moles (33.3%) remitted complelely, while the remaining 6(66.7%) progressed to PGTD. All aneuploid PHIMs underwent spontaneous remission. The S-phase of cell cycle in the CHMs studied was more frequent in those that progressed to persiatent GTDs, while G0/G1 was more frequent in those that remitted spontanemusly. The PHMs atudied failed to show any significant relationship between the phases of cell cycle and disease prognosis. Our results suggest the potentia] use of DNA ploidy and cell cycle analysis in prerlicting clinical outcome and thus in selecting cases for prophylactic chernotherapy.
