Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer.
- Author:
Fariz NURWIDYA
1
;
Fumiyuki TAKAHASHI
;
Akiko MURAKAMI
;
Kazuhisa TAKAHASHI
Author Information
1. Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan. fariz@juntendo.ac.jp
- Publication Type:Review
- Keywords:
Epithelial-mesenchymal transition;
Drug resistance;
Neoplasm metastasis;
Lung neoplasms
- MeSH:
Biology;
Drug Resistance;
Epithelial-Mesenchymal Transition;
Humans;
Incidence;
Lung;
Lung Neoplasms;
Morphogenesis;
Neoplasm Metastasis;
Recurrence
- From:Cancer Research and Treatment
2012;44(3):151-156
- CountryRepublic of Korea
- Language:English
-
Abstract:
Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.
