Meningeal Relapse in a Patient with Acute Promyelocytic Leukemia: A Case Report and Review of the Literature.
10.3346/jkms.2004.19.2.311
- Author:
Sung Hwa BAE
1
;
Hun Mo RYOO
;
Hee Soon CHO
;
Jae Lyun LEE
;
Kyung Hee LEE
;
Myung Soo HYUN
Author Information
1. Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, Korea. lkhee@medical.yeungnam.ac.kr
- Publication Type:Case Report ; Review
- Keywords:
Leukemia, Promyelocytic, Acute;
Central Nervous System;
Recurrence
- MeSH:
Adult;
Granulocyte Precursor Cells;
Human;
Leukemia, Promyelocytic, Acute/*cerebrospinal fluid/*diagnosis;
Male;
Meninges;
Recurrence
- From:Journal of Korean Medical Science
2004;19(2):311-314
- CountryRepublic of Korea
- Language:English
-
Abstract:
The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy.
