Association of Macrovascular Disease with Serum Lipoprotein(a) Levels in the Elderly .
- Author:
Ie Byung PARK
;
Kyung Hwan CHO
;
Sei Hyun BAIK
- Publication Type:Original Article
- Keywords:
Elderly;
Macrovascular disease;
Lipoprotein(a);
Lipid;
Risk factor
- MeSH:
Aged*;
Arteriosclerosis Obliterans;
Blood Glucose;
Body Mass Index;
Cholesterol;
Diabetic Foot;
Fasting;
Fibrinogen;
Heart Diseases;
Humans;
Hypertension;
Lipoprotein(a)*;
Logistic Models;
Middle Aged;
Myocardial Ischemia;
Peripheral Vascular Diseases;
Risk Factors;
Triglycerides
- From:Journal of the Korean Geriatrics Society
1998;2(2):68-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND : Lipoprotein(a)[Lp(a)] may be an independent risk factor for macrovascular disease in middle aged populations, but in elderly populations, Lp(a) levels to predict macrovascular risk is controversial. The purpose of this study is to evaluate the association of macrovascular disease with Lp(a) levels and lipid change in the elderly. METHODS : We have examined Lp(a) levels, lipid change and clinical, biochemical profile in 114 patients with macrovascular disease and 55 control subjects. Macrovascular disease was defined as ishemic heart disease and/or peripheral vascular disease, peripheral vascular disease was defined as arteriosclerosis obliterans, diabetic foot and/or cerebrovascular disease. RESULTS : Hypertension, diabetes were more prevalent and median Lp(a) levels, fasting blood glucose and HDL-cholesterol were significant higher in patients with macrovascular disease than control subjects, but there were no significant differences in age, body mass index, total cholesterol and triglycerides levels. Lp(a) levels were positively weak correlated with fibrinogen levels, but not correlated with age, body mass index, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides levels. In logistic regression analysis, there was no independent risk factor for ischemic heart disease, whereas diabetes, hypertension and low HDL-cholesterol levels were independent risk factors for peripheral vascular disease. CONCLUSION : Serum Lp(a) levels was not independent risk factor for macrovascular disease, but diabetes, hypertension and low HDL-cholesterol levels were independent risk factors for peripheral vascular disease. Therefore, the relationship between Lp(a) and lipid change and macrovascular disease in the elderly were different from middle aged subjects.
