1H Magnetic Resonance Spectroscopy of Primary Central Nervous System Lymphoma.
- Author:
Hui Joong LEE
1
;
Yong Sun KIM
Author Information
1. Department of Radiology, Kyungpook National University Hospital, Korea. knuhrad@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
CNS lymphoma;
CNS tumor;
Magnetic resonance spectroscopy
- MeSH:
Biopsy;
Central Nervous System*;
Choline;
Creatine;
Diagnosis;
Humans;
Lymphoma*;
Magnetic Resonance Spectroscopy*;
Medical Records;
Protons;
Retrospective Studies
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2004;8(2):86-93
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated 1H MR spectroscopy improves the preoperative diagnosis of diffuse infiltrative type of primary central nervous system lymphomas. MATERIALS AND METHODS: After review of conventional MR images and medical records, we retrospectively reviewed proton MR spectra in seven patients with primary central nervous system lymphoma diagnosed by means of biopsy. Relative ratio of choline (Cho), N-acetylaspartate (NAA), and lipid-lactate (Lip- Lac) to creatine (Cr) were measured for quantitative analysis. RESULTS: The average ratio of Cho/Cr was 1.80+/-0.95, NAA/Cr was 1.34+/-0.41, and Lip-Lac/Cr was 1.12+/-0.16. All cases of lymphomas showed increased Lip-Lac peak. Two case of mass forming lymphoma showed decreased NAA/Cr significantly, whereas five cases of lymphoma without mass formation showed preserved NAA/Cr. CONCLUSION: We thought the presence of Lip-Lac peak without significant reduction of NAA on the MR spectroscopy was helpful for diagnosis of diffuse infiltrative type of central nervous system lymphoma.
