Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates.
- Author:
Kyong Yeun JUNG
1
;
Sun Wook CHO
;
Young A KIM
;
Daein KIM
;
Byung Chul OH
;
Do Joon PARK
;
Young Joo PARK
Author Information
- Publication Type:Original Article
- Keywords: Tumor-associated macrophage; Prognosis; Neoplasms
- MeSH: Breast; Gallbladder; Gallbladder Neoplasms; Humans; Korea; Lung; Macrophages*; Neoplasm Metastasis; Pancreas; Prognosis; Survival Rate*; Thyroid Gland; Thyroid Neoplasms
- From:Journal of Pathology and Translational Medicine 2015;49(4):318-324
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Macrophages are a component of a tumor's microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers. METHODS: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry. RESULTS: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0+/-3.5%, 6.9+/-7.4%, and 6.9 +/- 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 +/- 1.6% vs anaplastic, 22.9 +/- 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers. CONCLUSIONS: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.
