Effect of Midazolam upon the Prevention of Nausea and Vomiting after Middle Ear Surgery.
10.4097/kjae.2007.52.5.550
- Author:
Jae Sik JUNG
1
;
Young Hun JEON
Author Information
1. Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. jeon68@knu.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
midazolam;
middle ear surgery;
postoperative nausea and vomiting (PONV)
- MeSH:
Anesthesia;
Antiemetics;
Ear, Middle*;
Humans;
Incidence;
Ketorolac;
Metoclopramide;
Midazolam*;
Nausea*;
Postoperative Nausea and Vomiting;
Prospective Studies;
Vomiting*
- From:Korean Journal of Anesthesiology
2007;52(5):550-555
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Midazolam has been reported to decrease postoperative nausea and vomiting (PONV). We studied the antiemetic effect of midazolam after middle ear surgery. METHODS: In this prospective, randomized, double-blind, placebo-controlled study, 90 healthy patients were scheduled for middle ear surgery (tympanomastoidectomy and tympanoplasty). Patients were randomly divided into two groups; Midazolam 0.075 mg/kg (n = 45) or normal saline (n = 45) was administered after induction of anesthesia. The incidence of PONV, metoclopramide and ketorolac usage, pain, sedation, and other side effects were assessed at 6, 24 h after the operation. RESULTS: The incidences of PONV were 15 (33%) in midazolam group and 27 (60%) in placebo group during 24 h postoperatively. The incidence of PONV in midazolam group was significantly lower than that in placebo group (P < 0.05). There were no significant differences between groups in adverse events. CONCLUSIONS: Midazolam 0.075 mg/kg was effective for preventing PONV after middle ear surgery without significant adverse effects.
