The Factors Associated with Typical Pattern of Brain SPECT in Alzheimer's Disease.
- Author:
Yong Tae KWAK
1
;
Il Woo HAN
;
Oh Young BANG
;
Chan H PARK
;
Min Seong KOO
Author Information
1. Department of Neurology, Yong-in Hyoja Hospital, Yongin.
- Publication Type:Original Article
- Keywords:
SPECT;
Alzheimer;
Dementia
- MeSH:
Alzheimer Disease*;
Brain*;
Consensus;
Dementia;
Diagnosis;
Functional Neuroimaging;
Humans;
Nuclear Medicine;
Population Characteristics;
Sex Education;
Tomography, Emission-Computed, Single-Photon*
- From:Journal of Korean Neuropsychiatric Association
2001;40(3):496-502
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: During the past few years, the development of functional brain imaging techniques has allowed to describe brain impairment in cognitive disorders. Among them, based on the observation of bilateral parietotemporal hypoperfusion in Alzheimer's disease(AD), single photon emission computed tomography(SPECT) is advocated by some as powerful diagnostic tool in the evaluation of demented patients. The aim of this study is to investigate the usefulness of SPECT in the diagnosis of AD and to clarify the associated factors of parietotemporal hypoperfusion, the typical SPECT pattern of Alzheimer's disease(AD). METHODS: We reviewed the SPECT scans of 26 patients fulfilling NINCDS-ADRDA criteria for probable AD, 14 with typical pattern of SPECT and 12 with atypical pattern of SPECT. Dementia severity was assessed by the Mini-Mental State Examination. Image interpretation was done visually by the consensus opinion of 2 experienced nuclear medicine physicians who were blind to clinical information. To estimate the association of typical pattern of SPECT with other variables of interest, discriminant function analysis was done. RESULTS: Though the overall diagnostic sensitivity of SPECT in AD was 53.8%, it was 76.9%, in early-onset AD patients. Typical pattern of SPECT was more frequent in the patients with early onset of the symptoms. Duration of symptoms, duration of education, sex, severity of disease was not associated with this SPECT pattern. CONCLUSION: These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset.
