Apolipoprotein E Polymorphism in Schizophrenic Patients.
- Author:
Young Sook CHOI
1
;
Chae Ki LIM
;
Chul Hyoung LYOO
Author Information
1. St. Andrew's Neuropsychiatric Hospital, Icheon.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Apolipoprotein E;
Genotype
- MeSH:
Apolipoproteins*;
Diagnostic and Statistical Manual of Mental Disorders;
Gene Frequency;
Genotype;
Humans;
Korea;
Polymerase Chain Reaction;
Protein Isoforms;
Schizophrenia
- From:Journal of Korean Neuropsychiatric Association
2001;40(3):503-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To explore the role of apolipoprotein E in schizophrenia, we investigated apoli-poprotein E polymorphism in groups of patients with schizophrenia and normal controls. We also examined the relationship of clinical characteristics of schizophrenia to apolipoprotein E genotypes. METHODS: Samples were obtained from 101 schizophrenic patients and 96 controls in Korea and apolipoprotein E polymorphisms were analysed using polymerase chain reaction. RESULTS: The genotype and allele frequencies did not differ from those of controls. The clinical variables of schizophrenia, such as positive and negative groups by PANSS, subtypes by DSM-IV, family history were not associated with each genotypes. CONCLUSION: We could not find the association of apolipoprotein E in Korean schizophrenic patients and it could be suggested that apolipoprotein E isoforms might not play a main role in expression of schizophrenia.
