Comparison of concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil versus cisplatin plus paclitaxel in patients with locally advanced cervical carcinoma.
- Author:
Eui Sok SOL
1
;
Tae Sung LEE
;
Suk Bong KOH
;
Hun Kyu OH
;
Gi Won YE
;
Youn Seok CHOI
Author Information
- Publication Type:Original Article
- Keywords: Cervical cancer; Chemoradiotherapy; Cisplatin; 5-fluorouracil; Paclitaxel
- MeSH: Chemoradiotherapy; Cisplatin; Fluorouracil; Humans; Hyponatremia; Leukopenia; Nausea; Neutropenia; Paclitaxel; Peripheral Nervous System Diseases; Retrospective Studies; Uterine Cervical Neoplasms
- From:Journal of Gynecologic Oncology 2009;20(1):28-34
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The aim of this study was to compare survival outcomes and toxicities between concurrent radiotherapy with cisplatin plus 5-fluorouracil and that with cisplatin plus paclitaxel in patients with locally advanced cervical carcinoma. METHODS: We retrospectively reviewed data from 93 locally advanced cervical carcinoma patients (stage IB to IVA) who had been treated by concurrent radiotherapy with cisplatin plus 5-fluorouracil (CF, n=45) vs. cisplatin plus paclitaxel (CP, n=48) as primary therapy. Toxicities and survival outcomes were compared. RESULTS: In the CP group, there were higher frequencies of severe (grade 3 or 4) leukopenia (79.2%, as compared to 11.1% in the CF group), severe neutropenia (77.1%, as compared to 8.9% in the CF group) and severe peripheral neuropathy (12.5%, as compared to 2.2% in the CF group). In the CF group, there were higher frequencies of severe nausea (33.3%, as compared to 14.6% in the CP group) and severe hyponatremia (11.1%, as compared to 0% in the CP group). Five-year DFS of the CF and CP groups was 67.4% and 79.1%, respectively (p=NS). Five year OS of the CF and CP groups was 79.6% and 80.9%, respectively (p=NS). CONCLUSION: Concurrent radiotherapy with cisplatin plus paclitaxel showed increased leukopenia, neutropenia and peripheral neuropathy, but less gastrointestinal toxicity (nausea) than that with cisplatin plus 5-fluorouracil. Survival outcome between these two groups was not statistically different in this study. Large prospective randomized controlled studies will be needed to confirm this result.
