Trends in cancer risk among South Korean patients infected with Human Immunodeficiency Virus.
- Author:
Young Mi SEOL
1
;
Moo Gon SONG
;
Young Jin CHOI
;
Sun Hee LEE
;
Sung Il KIM
;
Joo Seop CHUNG
;
Ihm Soo KWAK
;
Goon Jae CHO
;
Hyuck LEE
;
Dong Sik JUNG
;
Chi Sook MOON
;
Ji Young PARK
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. mdssampak@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
AIDS;
Human immunodeficiency virus;
Malignancy
- MeSH:
Acquired Immunodeficiency Syndrome;
Burkitt Lymphoma;
Carcinoma, Hepatocellular;
Electronics;
Electrons;
Esophageal Neoplasms;
Hemangiosarcoma;
HIV;
Humans;
Incidence;
Lymphocyte Count;
Lymphoma;
Lymphoma, B-Cell;
Lymphoma, Non-Hodgkin;
Male;
Prevalence;
Rectal Neoplasms;
Retrospective Studies;
Sarcoma, Kaposi;
Stomach Neoplasms;
Thyroid Neoplasms;
Tonsillar Neoplasms
- From:Korean Journal of Medicine
2009;76(5):554-563
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The prevalence of malignancies associated with human immunodeficiency virus (HIV) is rapidly increasing. The aim of the present study was to identify clinical features associated with malignancies in South Korean patients infected with HIV. METHODS: From January 1990 to June 2007, we reviewed an electronic database containing pathological reports obtained from HIV-infected patients and then retrospectively analyzed a total of 27 malignancy cases treated at four different institutions. RESULTS: Among 683 patients infected with HIV, malignant diseases were diagnosed in 27 cases (4.0%). Twenty-five of these patients were male, and the median age was 48 (range; 24-76). At the time of diagnosis, the median CD4+ lymphocyte count was 42/uL (range 3-339). Acquired immune deficiency syndrome (AIDS)-defining malignancies were diagnosed in 13 patients (48%) and non-AIDS-defining malignancies were diagnosed in 14 patients (52%). Two patients each were diagnosed with AIDS-defining and non-AIDS-defining malignancies during the pre-highly active anti-retroviral therapy (HARRT) period. In contrast, 11 patients (48%) and 12 patients (52%) were diagnosed with AIDS-defining and non-AIDS-defining malignancies during the HARRT period, respectively. Among AIDS-defining malignancies, non-Hodgkins lymphoma was the most frequently observed (9/13), followed by Kaposi's sarcoma (4/13). Among the 9 patients with non-Hodgkins lymphoma, diffuse large B-cell lymphoma was most common (5/9), followed by primary CNS lymphoma (3/9) and Burkitt's lymphoma (1/9). Gastrointestinal (GI) malignancies [i.e., gastric cancer (3/14), rectal cancer (3/14), and esophageal cancer (1/14)] and hepatocellular carcinoma (3/14) were the most commonly observed among the non-AIDS-defining malignancies. Other observed non-AIDS-defining malignancies were thyroid cancer (1/14), tonsillar cancer (1/14), angiosarcoma (1/14), and eccrine cancer (1/14). Finally, median CD4+ lymphocyte counts at the time of diagnosis were significantly different (18 vs. 114/uL, p=0.001) between AIDS-defining malignancies and non-AIDS-defining malignancies. CONCLUSIONS: Malignancies were diagnosed in 4.0% of patients infected with HIV. This study showed similar rates of incidence between AIDS-defining and non-AIDS-defining malignancies. Non-Hodgkins lymphoma was the most frequently observed malignancy, whereas GI malignancies and hepatocellular carcinoma were common among non-AIDS-defining malignancies.
